Ubiquitous Pharmacogenomics (U-PGx): The Time for Implementation is Now. An Horizon2020 Program to Drive Pharmacogenomics into Clinical Practice. Cecchin E, Roncato R, Guchelaar HJ, Toffoli G; Ubiquitous Pharmacogenomics Consortium. Curr Pharm Biotechnol. 2017;18(3):204-209. Posted on April 18, 2018May 14, 2019 by Wendy van Hemmen Continue reading →
Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects. Zhou Y, Ingelman-Sundberg M, Lauschke VM. Clin Pharmacol Ther. 2017 Oct;102(4):688-700. Posted on April 18, 2018May 14, 2019 by Wendy van Hemmen Continue reading →
Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies. Tamm R, Mägi R, Tremmel R, Winter S, Mihailov E, Smid A, Möricke A, Klein K, Schrappe M, Stanulla M, Houlston R, Weinshilboum R, Mlinarič Raščan I, Metspalu A, Milani L, Schwab M, Schaeffeler E. Clin Pharmacol Ther. 2017 May;101(5):684-695. Posted on April 18, 2018May 14, 2019 by Wendy van Hemmen Continue reading →
Translational learning from clinical studies predicts drug pharmacokinetics across patient populations. Krauss M, Hofmann U, Schafmayer C, Igel S, Schlender J, Mueller C, Brosch M, von Schoenfels W, Erhart W, Schuppert A, Block M, Schaeffeler E, Boehmer G, Goerlitz L, Hoecker J, Lippert J, Kerb R, Hampe J, Kuepfer L, Schwab M. NPJ Syst Biol Appl. 2017 Mar 28;3:11. Posted on April 18, 2018May 14, 2019 by Wendy van Hemmen Continue reading →
Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies. Viennas E, Komianou A, Mizzi C, Stojiljkovic M, Mitropoulou C, Muilu J, Vihinen M, Grypioti P, Papadaki S, Pavlidis C, Zukic B, Katsila T, van der Spek PJ, Pavlovic S, Tzimas G, Patrinos GP. Nucleic Acids Res. 2017 Jan 4;45(D1):D846-D853. Posted on April 18, 2018May 14, 2019 by Wendy van Hemmen Continue reading →
The importance of drug transporter characterization to precision medicine. Fisel P, Nies AT, Schaeffeler E, Schwab M. Expert Opin Drug Metab Toxicol. 2017 Apr;13(4):361-365. Posted on May 3, 2017May 14, 2019 by Wendy van Hemmen Continue reading →
Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium. van der Wouden CH, et al., Swen JJ, Guchelaar HJ; Ubiquitous Pharmacogenomics Consortium. Clin Pharmacol Ther. 2017 Mar;101(3):341-358. Posted on May 3, 2017May 14, 2019 by Wendy van Hemmen Continue reading →
A brighter future for the implementation of pharmacogenomic testing. van der Wouden CH, Swen JJ, Samwald M, Mitropoulou C, Schwab M, Guchelaar HJ. Eur J Hum Genet. 2016 Dec;24(12):1658-1660. Posted on May 3, 2017May 14, 2019 by Wendy van Hemmen Continue reading →
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron. Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez J, Sadhasivam S, Klein TE, Schwab M. Clin Pharmacol Ther. 2017 Aug;102(2):213-218. Posted on May 3, 2017May 14, 2019 by Wendy van Hemmen Continue reading →
Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors. Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT. Trends Pharmacol Sci. 2016 Nov;37(11):904-932. Posted on May 3, 2017May 14, 2019 by Wendy van Hemmen Continue reading →
