We want to make effective treatment optimization accessible to every European citizen
U-PGx: UBIQUITOUS PHARMACOGENOMICS
THE “PREPARE” CLINICAL STUDY
PHARMACOGENOMICS EDUCATIONAL MATERIAL
Pharmacogenomics (PGx) is the study of genetic variability affecting an individual’s response to a drug. Clinical application of pharmacogenomics knowledge will result in less ‘trial and error’ prescribing and more efficacious, safer and cost-effective drug therapy. However, despite the major advances in PGx and several commercially available PGx tests, its application in routine patient care remains very limited.
The U-PGx consortium will address major challenges and obstacles for implementation of PGx testing in patient care, taking into account the diversity of healthcare systems and citizens across Europe. Specifically, U-PGx will investigate if the emerging approach of pre-emptive genotyping of an entire panel of important PGx markers is cost-effective and results in a better outcome for patients. With the pre-emptive PGx testing approach data on multiple important pharmacogenes are collected prospectively and embedded into the patients’ electronic record. Typically, it alerts prescribers and pharmacists through electronic clinical decision support systems when a drug is ordered or dispensed for a patient with an at-risk genotype. The new model of personalised medicine through pre-emptive PGx-testing will be conducted at a large scale in seven existing European health care environments (The Netherlands, Spain, UK, Italy, Austria, Greece, Slovenia).
50% of elderly patients will receive drug treatment that could be optimized via PGx within the next four years.
98% of physicians think that PGx could help to better predict drug response.
Lack of knowledge
Only 10% of physicians feel they currently have adequate knowledge and tools for PGx.
Patients experience 30% fewer serious side effects when medication doses are tailored to their DNA. The study, published in The Lancet, is the first to demonstrate the practical application of[…]
We are delighted to announce the U-PGx Personalized Medicine Symposium that will be organized, as a HYBRID meeting, in Leiden, the Netherlands, March 30-31st, 2022. This event marks the completion of the U-PGx project.
September 29th, 2020 was a memorable day as Cristina Lucía Dávila Fajardo obtained her (second!) PhD degree from Leiden University in the Netherlands. Since 2010, she collaborates with Prof. Henk-Jan[…]
On September 2nd, 2020 Cathelijne van der Wouden obtained her PhD degree from Leiden University in the Netherlands. She started her PhD in 2016 in the research group of Prof.[…]
As per October 1st 2018, the PREPARE study sites have crossed-over to the opposite arm! Since then, more than 2,500 patients have been enrolled in the PREPARE study.
The 3rd U-PGx Personalized Medicine Public Day was successfully co-organized in Patras, Greece by the Golden Helix Foundation together with the University of Patras, Department of Pharmacy, Laboratory of Pharmacogenomics[…]
A practice paper “Educating the Next Generation of Pharmacogenomics Experts: Global Educational Needs and Concepts” analysing educational needs to develop pharmacogemomics from science to patient care and about our U-PGx[…]