Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients. Jukić MM, Haslemo T, Molden E, Ingelman-Sundberg M. Am J Psychiatry. 2018 May 1;175(5):463-470. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities. Lauschke VM, Barragan I, Ingelman-Sundberg M. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:161-185. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B. Arch Toxicol. 2018 Apr;92(4):1435-1451. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate. Rieger H, Schmidt P, Schaeffeler E, Abe M, Schiffhauer M, Schwab M, von Ahsen N, Zurek G, Kirchherr H, Shipkova M, Wieland E. Clin Chem Lab Med. 2018 Apr 25;56(5):803-809. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
Population pharmacogenomics: impact on public health and drug development. Patrinos GP. Pharmacogenomics. 2018 Jan;19(1):3-6. Posted on May 15, 2019May 15, 2019 by Wendy van Hemmen Continue reading →
Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients. Mitropoulos K, et al., Katsila T, Patrinos GP. Hum Genomics. 2017 Dec 8;11(1):30. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
Genetic variation in human drug-related genes. Schärfe CPI, Tremmel R, Schwab M, Kohlbacher O, Marks DS. Genome Med. 2017 Dec 22;9(1):117. doi: 10.1186/s13073-017-0502-5. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments. Lauschke VM, Milani L, Ingelman-Sundberg M. AAPS J. 2017 Nov 27;20(1):4. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
Measuring the Value of Pharmacogenomics Evidence. Patrinos GP, Mitropoulou C. Clin Pharmacol Ther. 2017 Nov;102(5):739-741. Posted on May 15, 2019May 15, 2019 by Wendy van Hemmen Continue reading →
Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics. Santos M, Niemi M, Hiratsuka M, Kumondai M, Ingelman-Sundberg M, Lauschke VM, Rodríguez-Antona C. Genet Med. 2018 Jun;20(6):622-629. Posted on May 15, 2019 by Wendy van Hemmen Continue reading →
