What is the study design of PREPARE?
PREPARE is designed as a multi-center, open, randomized, cross-over study. The sequence of study and control arm is randomized per country to minimize the influence of time dependent variables.
The 7 participating countries were randomized to start with:
1) Implementing pre-emptive PGx testing to guide drug and dose selection (study arm): Greece, Slovenia and Spain
2) Providing standard clinical care (control arm): Netherlands, Austria, Italy and UK