The importance of drug transporter characterization to precision medicine.

The aim of precision medicine is to improve health care by tailoring drug treatment to patients’ individual characteristics through the integration of knowledge explaining interindividual variability of drug response caused by an interaction of genetic and epigenetic factors as well as environmental and lifestyle factors. Desired drug effects are essentially dependent on the processes of drug absorption, distribution metabolism, and excretion (ADME) of therapeutic compounds. In order to understand the underlying mechanisms of interindividual variability in drug efficacy and safety, major research efforts have been spent on characterizing proteins involved in ADME processes, such as drug-metabolizing enzymes or drug transporters, during the last decades. Fisel P, Nies AT, Schäffeler E, Schwab M. Exp Opin Drug Metabol Toxicol. Apr 2017; 13(4):361-365.

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