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Publications

The Importance of Gene-Drug-Drug-Interactions in Pharmacogenomics Decision Support: An Analysis Based on Austrian Claims Data

Posted on April 18, 2018 by Wendy van Hemmen

While pharmacogenomic testing combined with clinical decision support has the potential to increase the safety and efficacy of medical treatments, the intake of multiple prescription drugs can Continue reading →

Posted in Publications

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels

Posted on April 18, 2018 by Wendy van Hemmen

Methyleugenol is a rodent hepatocarcinogen occurring in many herbs and spices as well as essential oils used for flavoring. Following metabolic activation by cytochromes P450 (CYPs) and sulfotransferases (SULTs), Continue reading →

Posted in Publications

Pharmacometabolomics Informs Quantitative Radiomics for Glioblastoma Diagnostic Innovation

Posted on April 18, 2018 by Wendy van Hemmen

Applications of omics systems biology technologies have enormous promise for radiology and diagnostics in surgical fields. In this context, the emerging fields of radiomics Continue reading →

Posted in Publications

Application of the DruGeVar Database in Cancer Genomics and Pharmacogenomics

Posted on April 18, 2018 by Wendy van Hemmen

In the post-genomic era, there is an increasing and urgent need for managing and visualizing big data. Data complexity and size will turn information growth into knowledge growth only if presented in a comprehensive and user-friendly way. Continue reading →

Posted in Publications

Exosomes: A Cancer Theranostics Road Map

Posted on April 18, 2018 by Wendy van Hemmen

Interindividual variability is yet to be fully characterized, and for this, optimum patient stratification and companion diagnostics are still lacking. Especially when complex disease phenotypes and/or polygenic diseases are considered, Continue reading →

Posted in Publications

Ubiquitous Pharmacogenomics (U-PGx): The Time for Implementation is Now. An Horizon2020 Program to Drive Pharmacogenomics into Clinical Practice

Posted on April 18, 2018 by Wendy van Hemmen

Although the clinical validity of a number of pharmacogenetic markers is nowadays a matter of fact, and led authoritative scientific consortia as the Dutch Pharmacogenetic Working Group (DPWG) and Continue reading →

Posted in Publications

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects

Posted on April 18, 2018 by Wendy van Hemmen

Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic activity toward a plethora of clinically important medications. Thus, single nucleotide variants and copy number variations in CYP genes Continue reading →

Posted in Publications

Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies

Posted on April 18, 2018April 18, 2018 by Wendy van Hemmen

Thiopurine-related hematotoxicity in pediatric acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases has been linked to genetically defined variability in thiopurine S-methyltransferase (TPMT) activity. Continue reading →

Posted in Publications

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

Posted on April 18, 2018April 18, 2018 by Wendy van Hemmen

Early indication of late-stage failure of novel candidate drugs could be facilitated by continuous integration, assessment, and transfer of knowledge acquired along pharmaceutical development programs. Continue reading →

Posted in Publications

Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies

Posted on April 18, 2018April 18, 2018 by Wendy van Hemmen

FINDbase (http://www.findbase.org) is a comprehensive data repository that records the prevalence of clinically relevant genomic variants in various populations worldwide, such as Continue reading →

Posted in Publications

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Recent Posts

  • 4th U-PGx Personalized Medicine Day
  • U-PGx Summer School “Towards Pharmacogenomics in Clinic”
  • The 3rd U-PGx Personalized Medicine Day, ”Pharmacogenomics in Oncology: Deciphering the Ethical, Legal and Societal Issues”
  • First 1,000 patients enrolled!
  • Population modeling in patients with sunitinib-treated cancer
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 668353.