Multidrug and toxin extrusion (MATE; SLC47A) proteins are membrane transporters mediating the excretion of organic cations and zwitterions into bile and urine and thereby contributing to the hepatic and renal elimination of many xenobiotics. Transported substrates include creatinine as endogenous substrate, Continue reading
The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to inter-individual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically Continue reading
Component I ‘Enabling pre-emptive testing’ would like to inform all partners that the IT decision support infrastructure works in all three intervention-first implementation sites! This includes for example that the genotyping platforms and card printers are operational and the genotype-haplotype-phenotype translation table has been approved. Continue reading
Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application into routine care remains limited. Opportunely, several implementation studies and programmes have been initiated over recent years. This article presents an overview of these studies and identifies current research gaps. Continue reading
After Granada, Liverpool, Patras and Aviano have also received ethical approval for the PREPARE study protocol. Liverpool only needs to receive approval from the Royal Liverpool R&D department (NHS). In Leiden and Ljubljana approval is awaited. In Vienna, there is a discussion whether or not the study is categorized as drug trial, but they have permission to start with the control arm. We expect to have all approvals in place at the end of January.
Again exciting news. Cristina Fajardo (Granada, Spain) has just announced that the ethical committee of Andalucia has approved the protocol! The team in Granada is now working on the final preparations and is then ready to start. Continue reading
After the submission of the PREPARE study protocol in Spain, Italy and Austria, the other four countries, i.e. Greece, Slovenia, UK and the Netherlands, have now also submitted the protocol to their respective IRBs. Hopefully we will soon receive the first approvals so we can start recruiting patients.
After Spain, also CRO Aviano in Italy and the Medical University of Vienna in Austria have submitted the PREPARE protocol to their respective IRBs.
Exciting news! The group in Granada, Spain, is the first who has submitted the PREPARE study protocol! Hopefully more will follow soon. We will keep you posted.
This U-PGx video (6 minutes) visualises and promotes the idea of personalised medicine and pre-emptive PGx testing. The video can be be used to inform the public via the webpage, for educational purpose and for communication with stakeholders and at (inter)national workshops. Continue reading