Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.

Multidrug and toxin extrusion (MATE; SLC47A) proteins are membrane transporters mediating the excretion of organic cations and zwitterions into bile and urine and thereby contributing to the hepatic and renal elimination of many xenobiotics. Transported substrates include creatinine as endogenous substrate, Continue reading

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application into routine care remains limited. Opportunely, several implementation studies and programmes have been initiated over recent years. This article presents an overview of these studies and identifies current research gaps.  Continue reading

Ethical approval at 4 clinical sites

After Granada, Liverpool, Patras and Aviano have also received ethical approval for the PREPARE study protocol. Liverpool only needs to receive approval from the Royal Liverpool R&D department (NHS). In Leiden and Ljubljana approval is awaited. In Vienna, there is a discussion whether or not the study is categorized as drug trial, but they have permission to start with the control arm. We expect to have all approvals in place at the end of January.

PREPARE protocol submitted by all 7 sites

After the submission of the PREPARE study protocol in Spain, Italy and Austria, the other four countries, i.e. Greece, Slovenia, UK and the Netherlands, have now also submitted the protocol to their respective IRBs. Hopefully we will soon receive the first approvals so we can start recruiting patients.